Your Gut Runs
Everything.
Trillions of microbes in your digestive system silently govern your immunity, your mood, your metabolism — and how long you live. The science is undeniable. Your habits haven't caught up yet.
The core science
Why Your Gut Is Everything
Your Gut Microbiome Is Unique to You
Like a fingerprint, your microbial community is entirely your own — shaped by birth, diet, environment, and lifestyle. No two microbiomes are alike. And yours changes every single day.
The Gut Trains Your Immune System
70% of immune tissue lines the gut wall. Every day, immune cells in your gut decide what's a threat and what isn't.
Gut Controls 95% of Your Serotonin
The gut-brain axis is a two-way highway. Gut bacteria produce most of your serotonin — the neurotransmitter governing mood and wellbeing.
Leaky Gut Drives Chronic Disease
A compromised gut barrier lets toxins into the bloodstream, triggering systemic inflammation — the silent driver of heart disease, diabetes, and neurodegeneration.
Centenarians Have Richer Microbiomes
Studies of 100-year-olds consistently show higher microbial diversity and unique bacterial signatures absent in average populations.
24-hour breakdown
Your Gut Never Stops Working
Morning Activation
Your gut microbiome wakes with you. Cortisol spikes trigger peristaltic contractions — the 'morning push' that moves last night's digestion forward. Bacteria begin producing short-chain fatty acids (SCFAs) from overnight fermentation.
Research from
Peer-reviewed evidence
The Research
Speaks for Itself
Published in Nature, Cell, Science & NEJM — the most cited gut health findings of the last decade.
Unique gut microbiome signatures predict healthy ageing and survival in older adults
Analysing over 9,000 adults, researchers found that individuals whose gut microbiomes became more compositionally unique over time had better health outcomes, higher mobility, lower blood cholesterol, and lived significantly longer — even after adjusting for age and diet.
Wilmanski T, Diener C, Rappaport N, et al.
High-fibre diet increases microbiome diversity; fermented foods reduce inflammation markers
A Stanford RCT found fermented food diets consistently reduced 19 inflammatory proteins and increased microbiome diversity across all participants — outperforming high-fibre diets for immune modulation.
Wastyk HC, Fragiadakis GK, Perelman D, et al.
Specific gut bacteria genera consistently associated with higher quality of life and lower depression
The largest gut-brain population study to date (n=1,063) linked Coprococcus and Dialister abundance with positive mental health markers, and found these genera systematically depleted in people diagnosed with depression.
Valles-Colomer M, Falony G, Darzi Y, et al.
Western diet rapidly degrades microbiome diversity — effects accumulate across generations
Switching to a low-fibre Western diet caused measurable microbiome degradation within 72 hours. Critically, lost diversity was only partially recoverable — and multigenerational loss compounds with each generation.
Sonnenburg JL, Bäckhed F.
Gut microbiome composition independently predicts 10-year cardiovascular disease risk
A landmark NEJM analysis showed that gut microbiome composition explains up to 31% of variance in cardiovascular risk — more than many traditional risk factors — and that dietary intervention targeting the gut reduced TMAO-driven atherosclerosis markers.
Komaroff AL, Bhatt DL.
All studies are independently published and peer-reviewed. FOXO does not conduct or fund these studies. Citations link directly to original journal sources.
Got questions?
Frequently Asked Questions
Everything you need to know about gut health, the microbiome, and what FOXO is building.
Join the WaitlistThe gut microbiome is the community of trillions of bacteria, fungi, and other microorganisms living in your digestive tract. It regulates immunity, metabolism, mood, and inflammation — making it one of the most influential systems in your body.
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